The Prescription for Long Life:

Microbes, Man and Medicine

Tuesday April 9, 2019: Manhattan

CAIPA Manhattan
202 Canal Street, 5FL, New York, NY 10013

Speaker:

Henry C. Lin, MD
Professor of Medicine
Division of Gastroenterology and Hepatology
University of New Mexico

"I am currently Chief of Medicine at the New Mexico VA Health Care System and Professor of Medicine with Tenure and Vice Chair, Department of Medicine, The University of New Mexico, Albuquerque, New Mexico, USA. My previous academic appointments were with the University of California, Los Angeles and the University of Southern California. Throughout my career, I have conducted bench-to-bedside translational research in the areas of GI motility and the interaction between gut microbiome and the host. These interest led me to propose more than 25 years ago a bacterial explanation for irritable bowel syndrome and other functional disorders."

Presentation Summary:

We are colonized by microbes upon birth so that by the 4th week of life, >1000 species numbering ~100 trillion take up residence in the gastrointestinal tract. Transfer of maternal gut microbiome to the newborn can occur outside of vaginal delivery. Amazingly, the gut of infants delivered by C-section could be colonized by mother’s gut microbes via breast milk. Breast milk is also a source of critical prebiotics for the newly settled gut microbiome. As a byproduct of microbial fermentation, short chain fatty acids support nutrition and regulates the metabolism of the host. A link between gut microbes and obesity is supported by data showing that gut microbes promotes fat storage by suppressing intestinal expression of fasting induced adipocyte factor (FIAF), an inhibitor of lipoprotein lipase (LPL)(lower FIAF, higher LPL, more fat stored). The role of gut microbes was highlighted when fat mass increased significantly in germ-free mice that have received stool from obese human donors. In an animal model of metabolic syndrome induced by a high-fat diet, antibiotic treatment improved the blood glucose profile, decreased liver fat load, improved leaky gut and lowered endotoxemia demonstrating the importance of the gut microbiome in this condition. Antibiotic treatment during early childhood is associated with higher body mass index. Exposing pregnant women in their 2nd or 3rd trimester to antibiotics increases the risk of obesity in the yet-to-be-born child. New insight into the intimate relationship between gut microbes and the host has greatly expanded our understanding of many diseases and offer promise of novel therapy.

Registration & Food will be from 6:45 PM to 7:00 PM

The talk will begin promptly at 7:00 PM. Please be on time.

Q/A will be from 8:30 PM to 9:00 PM

JOINTLY PROVIDED BY MAIMONIDES MEDICAL CENTER, CHARLES B. WANG COMMUNITY HEALTH CENTER, CHINESE AMERICAN MEDICAL SOCIETY, COALITION OF ASIAN-AMERICAN IPA, INC. & HEALTHFIRST

FOR JOINTLY SPONSORED ACTIVITIES
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Medical Society of the State of New York (MSSNY) through the joint sponsorship of Maimonides Medical Center and Charles B. Wang Community Health Center, Coalition of Asian-American IPA, Inc., Chinese American Medical Society and Healthfirst. Maimonides Medical Center is accredited by The Medical Society of the State of New York (MSSNY) to provide continuing medical education for physicians.

CREDIT DESIGNATION
The Maimonides Medical Center designates this Live activity for a maximum of 2.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.